Kisspeptin-10 impurity profile
Every named species the index has reported alongside Kisspeptin-10, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.72%
n=76
Median largest single
0.40%
n=76
Worst single observed
0.89%
n=76
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| oxidised Trp (+16 Da) | -0.34 | +15.995 | 95% | 0.21 | 0.87 |
| C-terminal free acid (+1 Da) | +0.18 | +0.984 | 91% | 0.11 | 0.77 |
| des-Tyr (−163 Da) | -0.56 | -163.063 | 89% | 0.13 | 0.66 |
| [D-Trp]-epimer | -0.12 | mass-identical | 88% | 0.10 | 0.89 |
oxidised Trp (+16 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 72 of 76 records (95 %)
- Level when reported
- median 0.21 %, max 0.87 %
- How it separates
- Baseline-resolved on the reference method.
C-terminal free acid (+1 Da)
- Retention offset from the main peak
- +0.18 min on RG-2
- Mass difference
- +0.984 Da
- Reported in
- 69 of 76 records (91 %)
- Level when reported
- median 0.11 %, max 0.77 %
- How it separates
- Close-eluting on the reference method, and merged with the main peak on a short gradient. The index prints the resolution figure for such a pair and applies no criterion to it — where the two are not separated, what matters is that the integration convention is stated.
des-Tyr (−163 Da)
- Retention offset from the main peak
- -0.56 min on RG-2
- Mass difference
- -163.063 Da
- Reported in
- 68 of 76 records (89 %)
- Level when reported
- median 0.13 %, max 0.66 %
- How it separates
- Baseline-resolved on the reference method.
[D-Trp]-epimer
- Retention offset from the main peak
- -0.12 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 67 of 76 records (88 %)
- Level when reported
- median 0.10 %, max 0.89 %
- How it separates
- Chromatography only. A gradient long enough to separate it; no mass spectrometer of any resolution will.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- Trp oxidation
- C-terminal amide hydrolysis — the amide is required for activity