Ipamorelin impurity profile
Every named species the index has reported alongside Ipamorelin, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.53%
n=204
Median largest single
0.28%
n=204
Worst single observed
1.27%
n=204
Named species observed
5 / 5
n=5
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| des-Lys (−128 Da) | -0.22 | -128.095 | 92% | 0.08 | 0.96 |
| [D-Trp]-epimer | -0.12 | mass-identical | 82% | 0.07 | 1.14 |
| oxidised Trp (+16 Da) | -0.34 | +15.995 | 78% | 0.13 | 1.27 |
| C-terminal free acid (+1 Da) | +0.18 | +0.984 | 77% | 0.07 | 0.89 |
| Aib-deletion sequence (−85 Da) | -0.28 | -85.053 | 77% | 0.06 | 0.83 |
des-Lys (−128 Da)
- Retention offset from the main peak
- -0.22 min on RG-2
- Mass difference
- -128.095 Da
- Reported in
- 188 of 204 records (92 %)
- Level when reported
- median 0.08 %, max 0.96 %
- How it separates
- Close-eluting on the reference method, and merged with the main peak on a short gradient. The index prints the resolution figure for such a pair and applies no criterion to it — where the two are not separated, what matters is that the integration convention is stated.
[D-Trp]-epimer
- Retention offset from the main peak
- -0.12 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 167 of 204 records (82 %)
- Level when reported
- median 0.07 %, max 1.14 %
- How it separates
- Chromatography only. A gradient long enough to separate it; no mass spectrometer of any resolution will.
oxidised Trp (+16 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 159 of 204 records (78 %)
- Level when reported
- median 0.13 %, max 1.27 %
- How it separates
- Baseline-resolved on the reference method.
C-terminal free acid (+1 Da)
- Retention offset from the main peak
- +0.18 min on RG-2
- Mass difference
- +0.984 Da
- Reported in
- 157 of 204 records (77 %)
- Level when reported
- median 0.07 %, max 0.89 %
- How it separates
- Close-eluting on the reference method, and merged with the main peak on a short gradient. The index prints the resolution figure for such a pair and applies no criterion to it — where the two are not separated, what matters is that the integration convention is stated.
Aib-deletion sequence (−85 Da)
- Retention offset from the main peak
- -0.28 min on RG-2
- Mass difference
- -85.053 Da
- Reported in
- 157 of 204 records (77 %)
- Level when reported
- median 0.06 %, max 0.83 %
- How it separates
- Close-eluting on the reference method, and merged with the main peak on a short gradient. The index prints the resolution figure for such a pair and applies no criterion to it — where the two are not separated, what matters is that the integration convention is stated.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- Trp oxidation on light exposure
- C-terminal amide hydrolysis