Cross-section

Cagrilintide by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for Cagrilintide, with a class minimum gradient of 25 min, the method is a live explanation.

54 recordsmedian 98.69 %spec 96.5 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Janoshik	29	30min	High	98.96	+0.00	98.96	ADEQUATE
PeptideMeter	8	28min	High	98.47	-0.05	98.52	ADEQUATE
VendorInvestigate	6 n=6	32min	High	97.96	-0.11	98.07	ADEQUATE
Medutest	5 n=5	25min	Unit	98.41	+0.08	98.33	ADEQUATE
Nordanalyt	4 n=4	35min	High	98.61	+0.02	98.59	ADEQUATE
Kestrel	2 n=2	15min	Unit	99.93, 99.50	+0.24	—	BELOW CLASS MINIMUM

Figure. Cagrilintide purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.