SLU-PP-332 impurity profile
Every named species the index has reported alongside SLU-PP-332, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
1.13%
n=22
Median largest single
0.60%
n=22
Worst single observed
0.91%
n=22
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| hydrolysed ester (+18 Da) | -1.24 | +18.011 | 100% | 0.20 | 0.91 |
| sulfoxide (+16 Da) | -0.72 | +15.995 | 100% | 0.18 | 0.59 |
| des-methyl analogue (−14 Da) | -0.36 | -14.016 | 100% | 0.15 | 0.85 |
| residual DMSO (process solvent) | -10.10 | mass-identical | 100% | 0.39 | 0.84 |
hydrolysed ester (+18 Da)
- Retention offset from the main peak
- -1.24 min on RG-2
- Mass difference
- +18.011 Da
- Reported in
- 22 of 22 records (100 %)
- Level when reported
- median 0.20 %, max 0.91 %
- How it separates
- Baseline-resolved on the reference method.
sulfoxide (+16 Da)
- Retention offset from the main peak
- -0.72 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 22 of 22 records (100 %)
- Level when reported
- median 0.18 %, max 0.59 %
- How it separates
- Baseline-resolved on the reference method.
des-methyl analogue (−14 Da)
- Retention offset from the main peak
- -0.36 min on RG-2
- Mass difference
- -14.016 Da
- Reported in
- 22 of 22 records (100 %)
- Level when reported
- median 0.15 %, max 0.85 %
- How it separates
- Baseline-resolved on the reference method.
residual DMSO (process solvent)
- Retention offset from the main peak
- -10.10 min on RG-2
- Mass difference
- mass-identical — chromatography only
- Reported in
- 22 of 22 records (100 %)
- Level when reported
- median 0.39 %, max 0.84 %
- How it separates
- Chromatography only. A gradient long enough to separate it; no mass spectrometer of any resolution will.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- ester hydrolysis in aqueous suspension
- thioether oxidation