PT-141 (Bremelanotide) impurity profile
Every named species the index has reported alongside PT-141 (Bremelanotide), how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.61%
n=152
Median largest single
0.33%
n=152
Worst single observed
1.37%
n=152
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| linear precursor (+18 Da) | -0.70 | +18.011 | 95% | 0.10 | 1.06 |
| oxidised Trp (+16 Da) | -0.34 | +15.995 | 91% | 0.14 | 0.99 |
| melanotan II (C-terminal amide, −1 Da) | +0.32 | -0.984 | 91% | 0.14 | 1.32 |
| des-acetyl (−42 Da) | -0.46 | -42.011 | 84% | 0.11 | 1.37 |
linear precursor (+18 Da)
- Retention offset from the main peak
- -0.70 min on RG-2
- Mass difference
- +18.011 Da
- Reported in
- 145 of 152 records (95 %)
- Level when reported
- median 0.10 %, max 1.06 %
- How it separates
- Baseline-resolved on the reference method.
oxidised Trp (+16 Da)
- Retention offset from the main peak
- -0.34 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 139 of 152 records (91 %)
- Level when reported
- median 0.14 %, max 0.99 %
- How it separates
- Baseline-resolved on the reference method.
melanotan II (C-terminal amide, −1 Da)
- Retention offset from the main peak
- +0.32 min on RG-2
- Mass difference
- -0.984 Da
- Reported in
- 138 of 152 records (91 %)
- Level when reported
- median 0.14 %, max 1.32 %
- How it separates
- Baseline-resolved on the reference method.
des-acetyl (−42 Da)
- Retention offset from the main peak
- -0.46 min on RG-2
- Mass difference
- -42.011 Da
- Reported in
- 128 of 152 records (84 %)
- Level when reported
- median 0.11 %, max 1.37 %
- How it separates
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- Trp oxidation
- lactam hydrolysis