IGF-1 LR3
Long R3 IGF-1 · LR3 IGF-1 · C400H625N111O116S9 · monoisotopic 9105.2412 Da. The index holds 118 assay reports on this compound across 17 batches from 14 suppliers.
Analytical fingerprint
Hand-authored chemistry. These properties describe the substance and do not change when a record is added.
IGF-1 LR3 is a recombinant 83-residue protein with three disulfide bonds, and it does not belong in an RP-HPLC purity workflow designed for synthetic peptides. The index reports it anyway, because it is submitted, but every LR3 record carries a method-suitability note: RP-HPLC on a C18 column measures hydrophobic heterogeneity, not correct folding, and a correctly-massed, 98 %-pure LR3 lot can still be entirely scrambled. SEC and non-reducing/reducing comparison are the informative methods and only two of the six index labs offer them. LR3 purity figures here should be read as an upper bound.
- Compound class
- Growth-hormone axis peptides
- Molecular formula
- C400H625N111O116S9
- Monoisotopic mass
- 9105.2412Da
- Average mass
- 9111.50Da
- Residues
- 83
- Nominal retention (RG-2, 30 min)
- 16.92min
- Retention window
- 0.50min
- Counter-ion as usually shipped
- acetate
- Typical label claims
- 0.1 mg · 1 mg
- Analytical difficulty (index scale)
- 1.60 — hard
- Purity is a defined quantity
- YES
Representative chromatogram
Drawn from this page's own medians. Not a scan, not an illustration, and not any single report.
What the index has observed
Arithmetic over the 118 records the index holds. Aggregates on this page are computed over the records the index holds, which are not a random sample of the material on the market. Lots that get tested are lots someone chose to test. Read every figure here as a description of this dataset rather than as an estimate of a population.
By supplier
Suppliers with fewer than two purity records on this compound are omitted from the figure rather than drawn as a line. The full table, including the thin cells, is on the by-supplier page.
Characteristic impurities and degradants
The left three columns are authored chemistry — what this molecule characteristically carries and where it elutes. The right three are what the index has actually reported.
| Named species | ΔRT (min, RG-2) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| disulfide-scrambled isomer | +0.62 | mass-identical | 100% | 0.36 | 2.06 |
| truncated (1-70) | -1.94 | -1385.688 | 100% | 0.13 | 1.61 |
| aggregated dimer | +3.20 | +9105.241 | 100% | 0.13 | 1.33 |
| oxidised Met59 (+16 Da) | -0.72 | +15.995 | 98% | 0.22 | 1.75 |
| des-13-residue N-extension (native IGF-1) | -2.24 | -1441.712 | 97% | 0.19 | 1.70 |
Degradation pathways
- disulfide scrambling — three disulfides, many wrong ways to pair them
- aggregation on freeze–thaw
- deamidation at multiple Asn
Full impurity profile, with what each named species implies about the synthesis →