Afamelanotide impurity profile
Every named species the index has reported alongside Afamelanotide, how often, at what level, and what its presence implies about the synthesis or the handling. Reporting threshold is 0.05 % area; anything below it is invisible to this page and is silently added to the main peak.
Median total impurities
0.94%
n=43
Median largest single
0.35%
n=43
Worst single observed
1.42%
n=43
Named species observed
4 / 4
n=4
| Named species | ΔRT (min) | Δ mass (Da) | Seen in | Median % area | Max % area |
|---|---|---|---|---|---|
| Met sulfoxide (+16 Da) | -0.44 | +15.995 | 100% | 0.27 | 1.19 |
| des-acetyl (−42 Da) | -0.52 | -42.011 | 100% | 0.21 | 0.87 |
| native α-MSH (−32 Da) | -0.66 | -32.037 | 98% | 0.15 | 0.36 |
| oxidised Trp (+16 Da) | -0.38 | +15.995 | 98% | 0.21 | 1.42 |
Met sulfoxide (+16 Da)
- Retention offset from the main peak
- -0.44 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 43 of 43 records (100 %)
- Level when reported
- median 0.27 %, max 1.19 %
- How it separates
- Baseline-resolved on the reference method.
des-acetyl (−42 Da)
- Retention offset from the main peak
- -0.52 min on RG-2
- Mass difference
- -42.011 Da
- Reported in
- 43 of 43 records (100 %)
- Level when reported
- median 0.21 %, max 0.87 %
- How it separates
- Baseline-resolved on the reference method.
native α-MSH (−32 Da)
- Retention offset from the main peak
- -0.66 min on RG-2
- Mass difference
- -32.037 Da
- Reported in
- 42 of 43 records (98 %)
- Level when reported
- median 0.15 %, max 0.36 %
- How it separates
- Baseline-resolved on the reference method.
oxidised Trp (+16 Da)
- Retention offset from the main peak
- -0.38 min on RG-2
- Mass difference
- +15.995 Da
- Reported in
- 42 of 43 records (98 %)
- Level when reported
- median 0.21 %, max 1.42 %
- How it separates
- Baseline-resolved on the reference method.
Degradation pathways
Degradants are a handling finding rather than a synthesis finding. A lot that shipped clean and arrived oxidised tells you about the courier, not the chemist.
- Met4 oxidation
- acetyl loss