Cross-section

Adipotide by laboratory

The same compound measured by different laboratories on different gradients. Where the medians differ, the question is whether the material differed or the method did — and for Adipotide, with a class minimum gradient of 15 min, the method is a live explanation.

22 recordsmedian 98.58 %spec 96.0 %

Laboratory	Reports	Gradient	MS resolution	Median purity %	Published bias (pp)	Bias-adjusted	Method suitability
Medutest	7 n=7	25min	Unit	97.73	+0.08	97.65	ADEQUATE
Janoshik	6 n=6	30min	High	98.68	+0.00	98.68	ADEQUATE
VendorInvestigate	4 n=4	32min	High	98.11	-0.11	98.22	ADEQUATE
Kestrel	3 n=3	15min	Unit	98.61	+0.24	98.37	ADEQUATE
PeptideMeter	2 n=2	28min	High	98.26, 98.69	-0.05	—	ADEQUATE
Nordanalyt	0	35min	High	—	+0.02	—	ADEQUATE

Figure. Adipotide purity by contributing laboratory. Any offset between rows has two possible sources — a real difference in the material each laboratory happened to receive, and the laboratory's own bias — and this figure cannot separate them. The paired analysis that can is on inter-lab agreement.