High resin substitution on a difficult sequence produces on-resin aggregation, and on-resin aggregation produces exactly this impurity pattern. It is a fixable process parameter and one of the commonest causes of a result in this band.
resin_loading
Resin substitution, loading and difficult-sequence aggregation on-resin.
Section 1
Contribution
Comments technically on records submitted by others. Annotations are signed and are not moderated for agreement.
Records submitted
0
n=0
Annotations
7
n=7
Median purity submitted
suppressed
n=0
n<3 — see individual records
Suppliers covered
0
n=0
This handle has submitted no records. Annotators comment on other people's submissions and are not required to submit.
Section 2
Annotations
Signed technical comments on records. The index does not moderate annotations for agreement with its own arithmetic, and several of these disagree with it. Where a handle has made the same point on several records, one instance is shown and the rest are reachable from the records themselves.
Purity 98.39 %, water 8.45 %, counter-ion 7.28 % acetate. Read together these say the cake is what it claims to be and the chromatographic homogeneity is the limiting property. That narrows the question usefully.
Purity 98.52 %, water 1.66 %, counter-ion 6.19 % acetate. Read together these say the cake is what it claims to be and the chromatographic homogeneity is the limiting property. That narrows the question usefully.
98.95 % on Selank is below the index specification for the class. The interesting part is the distribution: diketopiperazine (−18 Da) at 0.48 % is doing most of the work, and that species is a synthesis artefact rather than a degradation product. This is a process observation about lot CPC-2504-F9844, not a storage one.
Same conclusion here, from a different lot.
Showing 5 distinct comments of 7 annotations by this handle.